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PubMed COVID-19 Clinical Care

39821 - 39830 of 44979 results found

Frequent use of IGHV3-30-3 in SARS-CoV-2 neutralizing antibody responses

Date
Wednesday, April 12, 2023 - 4:00 AM
Description
The antibody response to SARS-CoV-2 shows biased immunoglobulin heavy chain variable (IGHV) gene usage, allowing definition of genetic signatures for some classes of neutralizing antibodies. We investigated IGHV gene usage frequencies by sorting

Newborn Screening in a Pandemic-Lessons Learned

Date
Tuesday, April 11, 2023 - 4:00 AM
Description
The COVID-19 pandemic affected many essential aspects of public health, including newborn screening programs (NBS). Centers reported missing cases of inherited metabolic disease as a consequence of decreased diagnostic process quality during the

Evolution of the SARS-CoV-2 mutational spectrum

Date
Tuesday, April 11, 2023 - 4:00 AM
Description
SARS-CoV-2 evolves rapidly in part because of its high mutation rate. Here we examine whether this mutational process itself has changed during viral evolution. To do this, we quantify the relative rates of different types of single nucleotide